- high intensity (high dose) statins are proven effective in reducing blood ‘bad
cholesterol’ levels of LDL-C
- combined therapy of high-intensity statin + ezetimibe, can reduce LDL-C
levels by an additional 13mg/DL compared to statins alone and reduce the
risk of death in patients who have already had a heart attack by 19%
- this combination therapy also showed a 49% reduction in all-cause mortality
and a 30% reduction in major adverse cardiovascular events, such as
stroke, compared to statins alone – Prof M. Banach, John Paul II University,
Lublin, Poland
- ‘combined’ cholesterol therapy should be considered immediately’ – Prof.
Peter Toth, Univ. Illinois, USA.
- from the 4.5 million deaths each year, worldwide, from high LDL-C
cholesterol, combined statin + ezetimibe therapy could prevent 330,000
deaths for those patients who have already suffered a heart attack – Prof.
Peter Toth, Univ. Illinois, USA.
- statins reduce production of LDL in the liver, while ezetimibe reduces the
absorption of LDL from food.
Source: Mayo Clinic study of 108,000 patients in a study
